Melatonin is considered the super drug for the brain, as it helps to reduce brain health problems and also eliminates cognitive dysfunction. Therefore, we will try to do a melatonin reviews, like how melatonin helps in the functioning of the brain.
How does melatonin work against free radicals? What are the side effects of melatonin and how can we get the recommended dosage?
Melatonin Reviews – What is It?
Melatonin is the hormone that is produced in the pineal gland. Now what is the pineal gland? The pineal gland is also called the “Seat of the Soul” and is located at the center of the brain.
So basically, melatonin is a brain hormone that is secreted by the pineal gland, which helps to receive information about the light and dark nature of the environment and helps to transfer this information to the brain.
The scientific name of melatonin is N-acetyl-5-methoxytryptamine, which is found in the pea sized pineal gland, also known as the third eye of the human.
How does Melatonin tablets work?
Basically, the work of melatonin is to convey the message of active and inactive modes to the brain, that is, when to sleep and when to rise. Therefore, melatonin is also referred to as the sleep hormone of the body.
Melatonin is a powerful antioxidant that helps in fighting against free radicals and also helps the mitochondria, the power house of the cell, retain the ATP synthesis process.
Similarly to the ALCAR, melatonin is also able to cross the BBB (Blood-brain-barrier). It helps in keeping the neural diseases off of the brain functioning, but sometimes the declination in its level can also disturb its functioning.
That declination occurs due to age related factors and interrupted communication between the nerve cells.
Related Reading: What is the best Brain Antioxidants?
How is Melatonin formed in the body?
Melatonin is the main interest of neuroscientists who are always studying more about it, as it functions like the brain’s own personal clock. The formation of melatonin depends upon the synthetization of an amino acid called L-tryptophan.
Now the role of L-tryptophan is to help the brain synthesize another important secretion called serotonin.
A neurotransmitter that helps in controlling stimulating hormones like dopamine, serotonin helps in keeping your mind healthy, calm and happy.
Coming back to melatonin, L-tryptophan is hydroxylated by the tryptophan hydroxylase. It is the enzyme responsible for hydroxylation.
After the hydroxylation, the product formed between L-tryptophan and 5-hydroxy L-tryptophan is carboxylate and serotonin is formed.
Through the present enzyme, the serotonin formed is converted into N-acetyl-serotonin by the present enzyme, and then, through the process of methylation, this N-acetyl-serotonin is converted into melatonin.
Melatonin and L-tryptophan work
L-tryptophan is the main fuel used for the production of Melatonin; however, the supply of L-tryptophan is very difficult for the body to produce, therefore, this supply comes from the food we eat in our daily life.
Like peanuts, bananas, oats, chicken, this makes melatonin a potential fighter against the germination of free radicals and gives you protection against Alzheimer’s disease and insomnia when the melatonin level is adequate in a human.
Melatonin was discovered in 1958 by a scientist that was naturally produced in the human body. It is said that the activation level of melatonin is just about two hours before daylight and two hours after nighttime. That indicates we sleep at night and wake up in the morning.
How does melatonin make you feel when you take it?
There are lots of functions that melatonin supports, but the main thing that comes into the picture is when melatonin is complied with the work of brain health.
Two main functions that can be spotted by brain health are mentioned below:
- Melatonin aids our natural sleeping process.
- Melatonin helps in fighting the neurodegenerative disease.
Melatonin aids our natural sleeping process.
The functioning of Melatonin in making our sleeping process smooth and regular was that Melatonin has its high activation time at two to four AM, meaning that the working mode of Melatonin is high at that time.
The action mode of the pineal gland that secretes melatonin was well reversed when the brain and the other organs were active and maintained the regulation of the circadian rhythm, a built-up clock in our body.
The sensitivity of circadian rhythm can be interrupted due to changes in the temperature and patterns of activity going on inside the brain. The level of cognition is also improved when there is a balanced melatonin level.
Melatonin Aids in the Treatment of Neurodegenerative Disease:
According to the research study, melatonin was found to cure Alzheimer’s and insomnia as it helps in improving the intracellular antioxidant reactions that prevent the oxidative damage from occurring in the brain activity patterns.
Melatonin not only helps in the stimulation of the longevity gene called SIRT1, but also helps in neuroplasticity.
It upregulates the protein associated with the growth of neurons called GAP43 and PSD-95. The controlling level of melatonin promotes the elimination of neurotoxicity and its anti-depressant actions help improve the circadian modulation of the brain.
Is melatonin very effective?
The benefits of this neurohormone melatonin, produced in the pineal gland from the synthetization of serotonin, are provided in various ways to the body, and here we have enlisted some of them as below:
Melatonin works as a natural clock.
Natural clock: It makes our body’s circadian rhythms and modulations, and it keeps our body’s biological setting time the same as it was programmed to do. This is called our “body clock.”
It is not a hypnotic drug but a sleep stabilizer that helps maintain the balance between sleep and waking up.
Melatonin lowers the cholesterol level.
Melatonin working is also linked with the cardiovascular system, which reduces the heart failure rate if there is an abundance of melatonin levels.
Also, with the use of melatonin as a supplement, the risk of bad cholesterol in our bodies is reduced by 38 percent, and the consumption of one mg of melatonin on a daily basis can control our blood pressure.
Melatonin helps in reducing the level of harmful stress hormones like norepinephrine and epinephrine. These two hormones have the worst effect on our brain health.
Melatonin can cure insomnia.
Insomnia is a sleeping disorder that occurs in humans as the lower quality of sleep is becoming a problem in today’s rushed life.
As a result, when a clinical trial was conducted and Melatonin was administered as a supplemental pill to people suffering from insomnia, it was discovered that the people were relieved of their sleeping disorder within 12 months of the trial.
This study concluded that melatonin aids patients’ recovery from shock and sleep irregularities.
Melatonin treats mild cognitive impairment.
Mild cognitive impairment is a serious cognitive problem that leads to the bigger problem of dementia. MCI is also known as the cognitive declination problem that helps between the normal aging stage.
But when the melatonin was given to the person in the form of medication, it was found that the person was able to perform better in mental state examinations and its metabolites helped the person to have better memory retention.
A Better Alternative to Benzos
Benzodiazepine is a drug that is used to treat patients who suffer from sleep depression; however, using benzodiazepine for sleep is extremely dangerous because it causes numerous side effects in the person.
It suppresses the natural formation of melatonin levels. The continuous use of benzodiazepines increases the risk of dementia, but if we increase the dose of melatonin instead of benzos, like having it at 3 to 5 mg daily.
Our subconscious level is improved and upregulated, and along with it, emotional performance is improved to initiate the sleep-awake cycle in patients.
Therefore, we must suggest you go for melatonin as your sleep drug.
What are the negative effects of taking melatonin?
However, there are negligible effects of consuming melatonin pills, but as a beginner, a person may feel the following:
- Sleep hangover.
- Decreased libido.
- Also, pregnant women must be barred from using melatonin.
What is the recommended dosage of melatonin?
The best start to having a melatonin supplement must be having half mg of melatonin 90 minutes before bedtime to see if it is suitable for our body and then we can go on to have other nootropic stacks with melatonin.
How to buy melatonin?
Melatonin can be consumed in pill form and it also comes in liquid and tablet form. Melatonin can be ordered from many famous online medication platforms like Performance Lab, and one can opt for Montmorency Cherry Tart.
- Adults take an 8 mg tablet daily.
- Children are allowed to take 3 mg daily.
Is melatonin worth taking? – Conclusion
Melatonin is the best neurohormone for treating insomnia and dementia-like problems. It has helped people facing jet lag and reduced the problem of daytime sleeping. It also helps people reduce migraine problems.
And taking melatonin in cases of anxiety and low levels of blood platelets has also shown positive effects on the patient, but one must not try it as a weight loss pill or in pregnancy as it can interfere with fertility rate.
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