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what is nootropic cycling

Nootropic Cycling Review 2024 – How Does It Work?

If you are not aware of proper nootropic cycling or if you are planning to start nootropics, this blog will provide a lot of information to do proper cycling. A good piece of biohacking content, on the other hand, will be found on blogs rather than books. There are so many things we can do to keep our brain performing at its peak.

Well, one such thing is nootropic cycling. It is a useful technique to enhance your brain performance and brain health. There is no one-size-fits-all. Some nootropics work best when taken occasionally, whereas some other nootropics work best when you consume them on a regular or repeated basis. Well, the best thing is to stick with a minimum dose and take maximum advantage of smart drugs.

Nootropic Cycling – What It Is?

what is nootropic cycling
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In simple words, nootropic cycling means consuming nootropics or smart drugs at a scheduled time rather than consuming them on a daily basis without a day off. Nootropic cycling is one of the best ways to avoid the trap of tolerance. If you want to get the maximum result, you should use the right cycling trick. 5:2 is considered to be an ideal dosage schedule for nootropics.

Nootropics are very effective for cognitive functions, but is it important to do cycling efficiently? However, tolerance is a very common symptom in the nootropic industry.

Developing tolerance is a good sign in a real situation like parenting or working. But it matters when it comes to nootropics. Whenever you notice that your brain is becoming tolerant of a nootropic or losing power, it’s time to switch to nootropic cycling and follow the right strategies to address them.

What Is Tolerance and the Reason for Tolerance?

In pharmaceuticals or nootropics, developing tolerance means that your body is becoming used to it and making the drugs less effective. To some extent, your body is likely to reach homeostasis. This condition is known as remaining constant or stable. Homeostasis is maintained throughout the body, like blood pressure, glucose levels, heart rate, temperature, and fluid balance to keep them stable.

Taking nootropics daily will lead to several downsides in brain functioning, such as diminishing the production of neurotransmitters, brain fog, etc. With intolerance, your body will become less responsive and less sensitive.

In contrast, you will not achieve what you are trying to achieve. When you continuously ingest chemicals or drugs, your body becomes used to them and they don’t provide the desired results.

In this undesirable situation, the only solution is to trick your brain and body into enjoying the same effects without side effects.

How To Avoid Tolerance

To avoid tolerance, it is not necessary to discontinue nootropics or take a higher dosage of nootropic drugs. The cycling pattern is generally different for everyone because everyone’s body reacts differently. Thus, there is no universal nootropic cycle.

The best you can do is to monitor your body, do research, and then develop a personal cycle based on experience.

Well, there are some ways to avoid tolerance while on nootropics. For some people, it could be days, weeks, or months before they take a break from nootropic drugs. However, 5:2 (taking nootropics for five days with weekends off) is considered an excellent cycle to get maximum benefits.

If you used nootropics for three months regularly, then you should take a month off before retaking it. Or you can also take smart drugs for one week and take a one-week break. So, this is how you can avoid nootropic tolerance.

Nootropic Cycling: Recommendations

As we all already discussed, there is no one-size-fits-all nootropic cycle. However, there are some guidelines you can follow to be protected from dangerous side-effects and help enhance your brain. Note that the below-mentioned cycles are commonly based on users’ experiences.


Anti-anxiety drugs like Phenibut are much more effective when taken for a few weeks. It is also recommended to take a break of two to three weeks before restarting the dosage.


The racetam family of nootropic drugs improves cycling performance. While some users have reported that racetams create tolerance when you stop these drugs suddenly. When you start with racetams, it is suggested that you use them for three to four months with one month off. Racetams with stimulants become more effective when used on alternate days.

Noopept Noopept is not a racetam but it provides similar results to racetams. Some users suggested taking it for five days on and two days off every three months, while others suggested taking it for 56 days on and four days off every three months.

Sulbutiamine: The best nootropic schedule for Sulbiamine is one week on and one week off.

Adrafinil: Adrafinil is not effective for long-term use. Schedule it either for 1 week with 2 weeks off or 3-4 times in a week.

Caffeine produces the best results when taken 2-3 times per week.

Choline-Choline cycling is not necessary because it is regarded as a nutrient that your body and brain require anyway.

Final Verdict

In nootropic cycling, less is more. It means when it comes to tolerance, consuming less will provide you more. Using the recommended or minimum dosage is always beneficial for better results and optimum performance. Remember that everyone’s body reacts differently to anecdotal evidence because it is not necessary that what one person has experienced or achieved will remain the same for you.

The best thing you can do is to track your cognitive abilities by participating in cognitive tests, and also monitor your diet and supplement schedule, do exercises as well as objective cognitive faculties and subjective mood to get an optimal outcome.

It will not just help to avoid tolerance, but you will also learn how these factors add to your brain performance and your body. Pay attention when using supplements and immediately discontinue them whenever you notice negative effects.

When you learn about the subtle changes in your body and brain, you can get the best results with a minimum nootropic dosage. Moreover, whenever you are starting nootropic supplements or others, it is good to consult a medical professional, especially when you are under any medication or starting to go with over-the-counter drugs.

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Matthew Swayne

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